Pioglitazone suspension and its aftermath: A wake up call for the Indian drug regulatory authorities

the association of vitamin d deficiency with colorectal cancer: a wake-up call for physicians and health authorities

although there is evidence that vitamin d deficiency leads to the development of several cancers, including colorectal cancer, research has shown gaps in establishing a relationship between hypovitaminosis d and the incidence of colorectal cancer. there are controversial reports and inadequate scientific evidence about the role of age and race-specific dosage of vitamin d supplementation for ch...

A wake-up call to CDA and provincial regulatory bodies.

Withdrawal of rofecoxib - a wake up call for drug safety.

yclooxygenase-2 (COX-2) inhibitors have been developed with the goal of providing similar efficacy and greater safety, compared with that of traditional Non-Steroidal Anti Inflammatory Drugs (NSAIDs). United States Food and Drug Administration (USFDA) has approved rofecoxib in May 1999 for the reduction of pain and inflammation caused by osteoarthritis, as well as for acute pain in adults and f...

A wake-up call for nutrition labelling.

In 2011, the European Union issued a new regulation on the provision of information on food for consumers (1). The regulation includes new directives for the provision of nutrition information on processed foods. In response, a number of food manufacturers and retailers recently committed themselves to harmonize the nutrition information on their products (2). In the USA in 2011, the Institute ...

Wake-up call for endothelial cells.

Among all known angiogenic molecules, vascular endothelial growth factor (VEGF) is probably the most extensively characterized growth factor that displays broad vascular functions including vasculogenesis, angiogenesis, vascular permeability, vascular survival, and vascular remodeling.1,2 These vascular functions of VEGF are mainly mediated by VEGF tyrosine kinase receptors (TKRs) expressed in ...